International Science Index


Design and Fabrication of Micro-Bubble Oxygenator


This paper applies the MEMS technology to design and fabricate a micro-bubble generator by a piezoelectric actuator. Coupled with a nickel nozzle plate, an annular piezoelectric ceramic was utilized as the primary structure of the generator. In operations, the piezoelectric element deforms transversely under an electric field applied across the thickness of the generator. The surface of the nozzle plate can expand or contract because of the induction of radial strain, resulting in the whole structure to bend, and successively transport oxygen micro-bubbles into the blood flow for enhancing the oxygen content in blood. In the tests, a high magnification microscope and a high speed CCD camera were employed to photograph the time evolution of meniscus shape of gaseous bubbles dispensed from the micro-bubble generator for flow visualization. This investigation thus explored the bubble formation process including the influences of inlet gas pressure along with driving voltage and resonance frequency on the formed bubble extent.

[1] Y. T. Shah, Gas–Liquid–Solid Reactor Design. McGraw-Hill, NewYork. 1979.
[2] P. A. Ramachandran, R. V. Chaudhari, Three-Phase Catalytic Reactors. Gordon and Breach Science, New York. 1983.
[3] A Kupferberg, G J Jameson, Bubble formation at a submerged orifice above a gas chamber of finite volume. Transactions of the Institute of Chemical Engineers, Vol. 47, pp 241-250, 1969.
[4] Kumar, R., Kuloor, N. R., The formation of bubbles and drops. Advances in Chemical Engineering Vol. 8, pp 255–368, 1970.
[5] D Azbel, Two-Phase Flows in Chemical Engineering. Cambridge University Press, Cambridge, UK. 1981.
[6] J N Lin, S K Banerji, H Yasuda, Role of interfacial tension in the formation and the detachment of air bubbles: a single hole on a horizontal plane immersed in water. Langmuir, Vol. 10, 936–942, 1994.
[7] M C Ruzicka, J Drahos, J Zahradnik, N H Thomas, Intermittent transition from bubbling to jetting regime in gas–liquid two phase flows. International Journal of Multiphase Flow, Vol. 23, pp 671–682, 1997.
[8] Y Zhang, Z Xiao, R B H Tan, Interfacial element modeling of bubble formation with liquid viscosity. Journal of Chemical Engineering of Japan, Vol. 38, pp 478–485, 2005.
[9] Z Xiao, R B H Tan, A model for bubble–bubble and bubble–wall interaction in bubble formation. A. I. Ch. E. Journal, Vol. 52, pp 86–98, 2006.
[10] R D La Nauze, I J Harris, Gas bubble formation at elevated system pressures. Transactions of the Institute of Chemical Engineers, Vol. 52, pp 337–348, 1974.
[11] K Idogawa, K Ikeda, T Fukuda, S Morooka, Formation and flow of gas bubbles in a pressurized bubble column with a single orifice or nozzle gas distributor. Chemical Engineering Communications, Vol. 59, pp 201–210, 1987.
[12] H Tsuge, Y Nakajima, K Terasaka, Behavior of bubbles formed from a submerged orifice under high system pressure. Chemical Engineering Science, Vol. 47, pp 3273–3280, 1992.
[13] P M Wilkinson, L L van Dierendonck, A theoretical model for the influence of gas properties and pressure on single-bubble formation at an orifice. Chemical Engineering Science, Vol. 49, pp 1429–1438, 1994.
[14] H Iwahashi, K Yuri, and Y Nose, Development of the oxygenator: past, present, and future. The Japanese Society for Artificial Organs, Vol. 7, pp 111-120, 2004.
[15] H K Yasuda, J N Lin, Small Bubbles Oxygenation Membrane. Journal of Applied Polymer Science, Vol. 90, pp 387-398, 2003.
[16] L Grinis, Y Monin, Influence of vibrations on gas bubble formation in liquids. Chemical Engineering Science, Vol. 5, pp 439-442, 1999.
[17] R Krishna, J Ellenberger, Improving gas-liquid mass transfer in bubble columns by applying low-frequency vibrations. Chemical Engineering Science, Vol. 25, pp 159-162, 2002.
[18] R Krishna, J Ellenberger, Influence of low-frequency vibrations on bubble and drop sizes formed at a single orifice. Chemical Engineering and Processing, Vol. 42, pp 15-21, 2003.